If you’ve been following the latest trends in aesthetic medicine, you’ve likely heard whispers about an unusual new treatment that’s taking the beauty world by storm. Salmon sperm DNA injections—also known as polynucleotide therapy—might sound like something out of a science fiction novel, but this cutting-edge treatment is backed by solid scientific research and delivering remarkable results for patients seeking natural skin rejuvenation.
At 740 Park Plastic Surgery, Dr. Stafford Broumand has been at the forefront of innovative aesthetic treatments, and polynucleotide therapy represents the next evolution in regenerative medicine. This revolutionary approach harnesses the power of purified DNA fragments to stimulate your skin’s natural healing and regeneration processes, offering a sophisticated alternative to traditional fillers and skin treatments.
What Are Salmon Sperm DNA Injections?
Polynucleotide injections utilize purified DNA fragments extracted from salmon sperm cells, specifically polydeoxyribonucleotides (PDRNs). Before you let the source material concern you, it’s important to understand that these DNA fragments undergo extensive purification and processing to create a sterile, biocompatible treatment that’s completely safe for human use.
The salmon DNA is chosen because it shares remarkable similarities with human DNA structure, making it highly compatible with our cellular processes. The final product is a clear, gel-like substance that contains concentrated polynucleotides—long chains of nucleotides that serve as the building blocks of DNA.
The Science Behind the Treatment
These purified DNA fragments work at the cellular level to activate your body’s natural repair mechanisms. Unlike traditional dermal fillers that simply add volume, polynucleotides actually communicate with your skin cells, triggering a cascade of regenerative processes that improve skin quality from within.
The treatment has gained significant attention in recent years, with celebrities like Kim Kardashian and Hailey Bieber publicly discussing their positive experiences with salmon DNA treatments, bringing this innovative therapy into the mainstream spotlight.
How Polynucleotides Work at the Cellular Level
Understanding how salmon sperm DNA injections work requires a look at the sophisticated biological processes they trigger within your skin. When polynucleotides are injected into the dermis, they initiate several key mechanisms that promote skin health and regeneration.
Fibroblast Stimulation and Collagen Production
The primary mechanism of action involves stimulating fibroblasts—the cells responsible for producing collagen, elastin, and other essential proteins that maintain skin structure and elasticity. Polynucleotides act as cellular messengers, encouraging fibroblasts to increase their activity and produce higher-quality collagen fibers.
This enhanced collagen production doesn’t just add volume; it improves the overall architecture of your skin, creating a more youthful, resilient foundation that continues to improve over time.
Enhanced Cellular Metabolism and Repair
Polynucleotides also boost cellular metabolism, improving the efficiency of cellular repair processes. This enhanced metabolic activity helps skin cells function more effectively, leading to better hydration, improved texture, and accelerated healing of minor damage from environmental factors.
Anti-Inflammatory Properties
Research has shown that polynucleotides possess significant anti-inflammatory properties, helping to calm irritated skin and reduce the chronic low-level inflammation that contributes to aging. This anti-inflammatory effect is particularly beneficial for patients with sensitive skin or conditions like rosacea.
Improved Vascularization
The treatment promotes angiogenesis—the formation of new blood vessels—which improves nutrient delivery and waste removal at the cellular level. This enhanced circulation contributes to the healthy glow that patients often notice after treatment.
Comprehensive Benefits for Skin Health
The multi-faceted approach of polynucleotide therapy delivers a wide range of benefits that address various aspects of skin aging and damage. Unlike single-purpose treatments, salmon sperm DNA injections provide comprehensive skin improvement.
Texture and Tone Enhancement
Patients consistently report significant improvements in skin texture and tone following polynucleotide treatments. The enhanced collagen production smooths rough areas, reduces pore appearance, and creates a more even skin surface. The improved cellular function also leads to better skin tone uniformity and a natural radiance.
Fine Line and Wrinkle Reduction
While not as dramatic as neurotoxin treatments for dynamic wrinkles, polynucleotides effectively address fine lines caused by collagen loss and skin thinning. The treatment is particularly effective for perioral lines, under-eye fine lines, and early signs of aging around the temples and cheeks.
Deep Hydration and Moisture Retention
One of the most immediate benefits patients notice is improved skin hydration. Polynucleotides enhance the skin’s ability to retain moisture by supporting the production of hyaluronic acid and improving the skin barrier function. This leads to plumper, more supple skin that maintains its hydration throughout the day.
Accelerated Healing and Recovery
The regenerative properties of polynucleotides make them excellent for patients recovering from other aesthetic procedures. The treatment can accelerate healing, reduce downtime, and improve final results when used in conjunction with laser treatments, chemical peels, or surgical procedures.
Long-Term Skin Quality Improvement
Unlike temporary treatments that provide immediate but short-lived results, polynucleotide therapy creates lasting improvements in skin quality. The enhanced collagen production and improved cellular function continue to benefit the skin for months after treatment completion.
What to Expect During Your Polynucleotide Treatment
Understanding the treatment process helps patients feel more comfortable and confident about their decision to pursue salmon sperm DNA injections. The procedure is relatively straightforward, but proper technique and expertise are essential for optimal results.
Initial Consultation and Assessment
Your journey begins with a comprehensive consultation where Dr. Broumand evaluates your skin condition, discusses your aesthetic goals, and determines if polynucleotide therapy is the right choice for you. This assessment includes examining skin quality, identifying areas of concern, and creating a customized treatment plan.
Treatment Protocol and Sessions
Most patients require a series of 3-4 treatment sessions spaced 2-3 weeks apart for optimal results. Each session takes approximately 30-45 minutes and involves multiple micro-injections using very fine needles. The treatment areas are thoroughly cleansed, and a topical anesthetic may be applied for comfort.
The Injection Process
During the procedure, small amounts of the polynucleotide solution are injected into the dermis using a precise technique that ensures even distribution. The injections are typically performed in a grid pattern across the treatment area, with special attention to areas of particular concern.
Immediate Post-Treatment Experience
Immediately following treatment, you may notice some mild swelling, redness, or small bumps at the injection sites. These effects are normal and typically resolve within 24-48 hours. Most patients can return to their normal activities immediately, though strenuous exercise should be avoided for 24 hours.
Results Timeline and Development
Unlike treatments that provide immediate results, polynucleotide therapy works gradually as your skin’s natural processes are enhanced. Initial improvements may be noticed within 2-3 weeks, with continued enhancement over the following 2-3 months as collagen production increases and cellular function improves.
Ideal Candidates for Polynucleotide Therapy
While polynucleotide treatments can benefit a wide range of patients, certain individuals are particularly well-suited for this innovative therapy. Understanding whether you’re an ideal candidate helps ensure the best possible outcomes.
Early Signs of Aging
Patients in their late 20s to early 40s who are beginning to notice the first signs of aging often see excellent results from polynucleotide therapy. The treatment is particularly effective for preventing and addressing early collagen loss, fine lines, and changes in skin texture.
Skin Quality Concerns
If your primary concerns relate to skin quality rather than significant volume loss, polynucleotides may be an ideal choice. The treatment excels at improving texture, tone, hydration, and overall skin health rather than providing dramatic volumization.
Natural Treatment Preferences
Patients who prefer treatments that work with their body’s natural processes rather than introducing synthetic materials often gravitate toward polynucleotide therapy. The biocompatible nature of the treatment appeals to those seeking natural-looking, gradual improvements.
Combination Treatment Candidates
Polynucleotides work exceptionally well as part of a comprehensive aesthetic treatment plan. They can enhance the results of other procedures and are often combined with treatments like microneedling, laser therapy, or traditional injectables for comprehensive rejuvenation.
Maintenance-Minded Patients
Individuals who are committed to maintaining their results through a series of treatments and understand that optimal outcomes require patience and consistency tend to be very satisfied with polynucleotide therapy.
Safety Profile and Potential Side Effects
One of the significant advantages of polynucleotide therapy is its excellent safety profile. The biocompatible nature of the treatment and the purification process minimize the risk of adverse reactions.
Common, Temporary Side Effects
The most common side effects are mild and temporary, typically resolving within 24-48 hours:
- Mild swelling at injection sites
- Temporary redness or pink discoloration
- Small bumps or papules where injections were administered
- Minor bruising (less common but possible)
- Slight tenderness or sensitivity in treated areas
Rare Complications
Serious complications are extremely rare with polynucleotide treatments when performed by qualified practitioners:
- Allergic reactions (primarily in patients with fish allergies)
- Infection (minimized through proper sterile technique)
- Granuloma formation (very rare with proper injection technique)
- Asymmetry or uneven results (typically correctable with additional treatment)
Contraindications and Precautions
Certain patients should avoid polynucleotide treatments or proceed with extra caution:
- Pregnant or breastfeeding women
- Patients with active skin infections in treatment areas
- Individuals with known fish or seafood allergies
- Patients with autoimmune conditions (requires careful evaluation)
- Those taking blood-thinning medications (may increase bruising risk)
The Scientific Evidence Supporting Polynucleotide Therapy
The effectiveness of salmon sperm DNA injections isn’t just anecdotal—it’s supported by a growing body of scientific research that demonstrates the treatment’s efficacy and safety.
Clinical Studies and Research Findings
Research published in the National Institutes of Health database has examined the effects of polynucleotide treatments on skin health and aging. A comprehensive review titled “Polynucleotides in Aesthetic Medicine: A Review of Current Applications” found that polynucleotides have been used to improve skin texture, reduce wrinkle depth, and enhance facial appearance with measurable clinical outcomes.1
Studies published in aesthetic medicine journals have demonstrated that polynucleotide injections show promising outcomes in reducing wrinkles, improving skin texture, and enhancing elasticity. The research indicates that patients experience continued improvement over several months following treatment completion.
Mechanism Validation
Scientific research published in ScienceDirect has confirmed the anti-aging properties of polydeoxyribonucleotide (PDRN) therapy. The study “Polydeoxyribonucleotide: A promising skin anti-aging agent” documented the benefits of PDRN therapy, including reversal of signs of aging with reduction of fine lines and wrinkles, and more elastic and firm skin texture due to enhanced collagen production.2
Laboratory studies have validated the proposed mechanisms of action for polynucleotides, demonstrating their ability to stimulate fibroblast activity, enhance collagen synthesis, and promote cellular repair processes through adenosine receptor activation.
Safety Profile Documentation
Clinical research has consistently shown that polynucleotide treatments have an excellent safety profile when administered by qualified practitioners. The biocompatible nature of purified salmon DNA and the extensive purification process minimize the risk of adverse reactions, with most side effects being mild and temporary.
The research supports polynucleotides as a safe and effective treatment option for patients seeking natural skin rejuvenation through regenerative medicine approaches.
Comparing Polynucleotides to Other Regenerative Treatments
Understanding how salmon sperm DNA injections compare to other regenerative aesthetic treatments helps patients make informed decisions about their care.
Polynucleotides vs. Platelet-Rich Plasma (PRP)
While both treatments harness the body’s natural healing processes, they work through different mechanisms. PRP uses growth factors from your own blood, while polynucleotides provide DNA-based cellular signals. Polynucleotides often provide more consistent results since the concentration and quality don’t depend on individual blood characteristics.
Polynucleotides vs. Traditional Dermal Fillers
Traditional hyaluronic acid fillers provide immediate volume but don’t improve skin quality. Polynucleotides work more gradually but create lasting improvements in skin health and structure. Many patients benefit from combining both approaches for comprehensive rejuvenation.
Polynucleotides vs. Microneedling
Microneedling creates controlled injury to stimulate healing, while polynucleotides provide direct cellular signals for regeneration. The treatments complement each other well and are often combined for enhanced results.
Cost-Effectiveness Considerations
While the initial investment in polynucleotide therapy may be higher than some alternatives, the long-lasting results and comprehensive skin improvements often provide excellent value. The treatment’s ability to improve multiple aspects of skin health simultaneously makes it cost-effective for patients seeking overall skin quality enhancement.
Maximizing Your Polynucleotide Treatment Results
Getting the best possible outcomes from your salmon sperm DNA injections requires proper preparation, realistic expectations, and appropriate aftercare.
Pre-Treatment Preparation
Optimizing your skin health before treatment can enhance results:
- Maintain a consistent skincare routine with quality products
- Stay well-hydrated in the weeks leading up to treatment
- Avoid excessive sun exposure and always use broad-spectrum sunscreen
- Discontinue blood-thinning supplements if medically appropriate
- Arrive at your appointment with clean, makeup-free skin
Post-Treatment Care Guidelines
Following proper aftercare instructions ensures optimal healing and results:
- Apply gentle, fragrance-free moisturizer to maintain hydration
- Avoid direct sun exposure for 48 hours post-treatment
- Skip intense exercise for 24 hours to minimize swelling
- Don’t massage or manipulate treated areas for the first week
- Use gentle skincare products and avoid harsh actives for several days
Lifestyle Factors That Enhance Results
Certain lifestyle choices can amplify the benefits of polynucleotide therapy:
- Maintain a healthy diet rich in antioxidants and essential nutrients
- Stay consistently hydrated to support cellular function
- Get adequate sleep to optimize natural repair processes
- Manage stress levels, as chronic stress can impair skin health
- Follow a comprehensive skincare routine with medical-grade products
Combination Treatment Strategies
Polynucleotide therapy often works synergistically with other aesthetic treatments, creating comprehensive rejuvenation protocols that address multiple aspects of aging.
Polynucleotides with Neurotoxins
Combining polynucleotides with BOTOX® or other neurotoxins addresses both dynamic wrinkles and skin quality concerns. The neurotoxin prevents muscle-related wrinkles while polynucleotides improve overall skin health and texture.
Integration with Laser Treatments
Polynucleotides can enhance recovery from laser treatments while providing additional skin quality benefits. The regenerative properties help optimize healing and may improve final results from laser resurfacing or skin tightening procedures.
Complementary Injectable Treatments
Strategic combination with traditional dermal fillers allows for comprehensive facial rejuvenation. Fillers restore volume while polynucleotides improve skin quality, creating natural-looking, harmonious results.
The Future of Polynucleotide Therapy
As research continues and technology advances, polynucleotide treatments are likely to become even more sophisticated and effective.
Emerging Applications
Researchers are exploring new applications for polynucleotide therapy, including hair restoration, body treatments, and enhanced wound healing protocols. These expanding applications may offer even more options for patients in the future.
Technological Advances
Improvements in extraction and purification techniques may lead to even more potent and effective polynucleotide formulations. Advanced delivery methods could also enhance treatment comfort and results.
Personalized Treatment Protocols
Future developments may include personalized polynucleotide treatments tailored to individual genetic profiles and specific skin concerns, optimizing results for each patient’s unique needs.
Frequently Asked Questions
How long do results from polynucleotide treatments last?
Results typically last 12-18 months, with some patients experiencing benefits for up to two years. The longevity depends on individual factors like age, skin condition, and lifestyle habits. Maintenance treatments can help sustain and enhance results over time.
Is the treatment painful?
Most patients describe the discomfort as minimal, similar to other injectable treatments. Topical anesthetic can be applied before treatment to enhance comfort. The fine needles used for injection minimize discomfort during the procedure.
Can polynucleotides be combined with other treatments?
Yes, polynucleotides work excellently in combination with other aesthetic treatments. They can be performed alongside or following treatments like Botox, dermal fillers, microneedling, or laser therapy for comprehensive rejuvenation.
How soon can I see results?
Initial improvements may be noticed within 2-3 weeks, with continued enhancement over 2-3 months as collagen production increases. The gradual nature of results creates natural-looking improvements that develop over time.
Are there any restrictions after treatment?
Post-treatment restrictions are minimal. Avoid strenuous exercise for 24 hours, direct sun exposure for 48 hours, and don’t massage treated areas for one week. Most normal activities can be resumed immediately.
Who should avoid polynucleotide treatments?
Patients with fish or seafood allergies, pregnant or breastfeeding women, and those with active skin infections should avoid treatment. A thorough consultation will determine if you’re a suitable candidate.
Experience the Future of Skin Rejuvenation
Salmon sperm DNA injections represent a paradigm shift in aesthetic medicine, offering a natural, scientifically-backed approach to skin rejuvenation that works with your body’s inherent healing processes. This innovative treatment provides comprehensive skin improvement that continues to enhance over time, making it an excellent investment in your long-term skin health.
At 740 Park Plastic Surgery, Dr. Stafford Broumand combines extensive expertise in aesthetic medicine with cutting-edge treatments like polynucleotide therapy to deliver exceptional results for his patients. His commitment to staying at the forefront of aesthetic innovation ensures that you receive the most advanced, effective treatments available.
If you’re ready to experience the transformative benefits of salmon sperm DNA injections and discover how this revolutionary treatment can enhance your natural beauty, we invite you to schedule a consultation with Dr. Broumand. During your personalized consultation, we’ll evaluate your skin, discuss your aesthetic goals, and create a customized treatment plan designed to help you achieve the radiant, youthful skin you desire.
Don’t let concerns about aging skin hold you back from feeling confident and beautiful. Contact 740 Park Plastic Surgery today to learn more about polynucleotide therapy and take the first step toward healthier, more vibrant skin that reflects your inner vitality.
Sources
1 Lee KWA, Chan KWL, Lee A, Lee CH, Wan J, Wong S, Yi KH. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. Int J Mol Sci. 2024 Jul 27;25(15):8224. doi: 10.3390/ijms25158224. PMID: 39125793; PMCID: PMC11311621. Available: https://pubmed.ncbi.nlm.nih.gov/39125793/. Accessed October 1, 2025.
2 Khan A, Wang G, Zhou F, Gong L, Zhang J, Qi L, Cui H. Polydeoxyribonucleotide: A promising skin anti-aging agent. Chinese Journal of Plastic and Reconstructive Surgery. 2022;4(4):187-193. doi:10.1016/j.cjprs.2022.09.015. Available: https://www.sciencedirect.com/science/article/pii/S2096691122000723. Accessed October 1, 2025.